Biofilm

Gas plasma treatment may be an effective method for disrupting Staphylococcus aureus biofilms and has the potential to remove challenge of persistence infection within a chronic wound thus allowing the wound to heal appropriately (1). No organisms were detected after 5 minutes treatment with the Adtec SteriPlas.

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Biofilm in wounds are considered to be one of the major challenges in infection management. Bacteria protected within biofilms are up to 1000 times more resistant to antibiotics… which severely complicates treatment options (2).

Wounds that contain biofilm may not be identified, resulting in ineffective treatment and delayed healing. Biofilm is recalcitrant to treatment with antibiotics or antiseptics. Debridement is one of the most important treatment strategies against biofilm, but it does not remove all biofilm and therefore cannot be used alone. Topical antiseptic application within this time dependent window can suppress biofilm reformation (3).

The Adtec SteriPlas has been proven in clinical trials and patient treatments to have antimicrobial efficacy, promoting wound healing even in problematic and non-healing wounds that are stalled by biofilm, such as diabetic foot ulcers and surgical site infections.

Leeds Teaching Hospital NHS Trust will be joining Salford Royal NHS Foundation Trust as a trial centre for our randomised controlled trial to evaluate the efficacy of non-thermal gas plasma on sub-clinical wound infection (biofilm) in patients with diabetic foot ulcers compared to those treated with standard care of dressings. The clinical team will be led by our clinical partners, Mr Dave Russell, and the Podiatry and Vascular Research Team in the Diabetes Limb Salvage Service at Leeds Teaching Hospitals. The Chief Investigator for the trial is Professor Steven Jeffery from HM Forces, Queen Elizabeth Hospital.

The hypothesis to be tested is that the healing of chronic diabetic foot ulcers that are stalled by biofilm can be accelerated following intervention with the Adtec SteriPlas.

The secondary objective is to correlate clinical presentation of long standing wounds as recorded through digital photographs in terms of wound volume/wound dimensions through wound microbiology (number of bacterial species present), biochemistry and histology in a series of diabetic foot ulcers.

1. Booth Wounds UK, 2015; 2. Environ Health Perspect. 2010 Jul; 118(7): A288; 3. Schultz et al. Wound Repair Regen 2017.

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