infection
Adtec Healthcare's new project with Hull York Medical School testing gas plasma on Osteomyelitis bone infections.
We are excited to announce the study “Gas Plasma for the Prevention and Management of Osteomyelitis Biofilms” has now begun at the Hull York Medical School. The study led by Dr Angela Oates and funded by the National Biofilms Innovation Centre will seek to test the efficacy of our gas plasma system on osteomyelitis bone infections using our PlasmaTact device. This project will develop a novel laboratory testing model to evaluate and optimise plasma treatment for osteomyelitis biofilm infections.
We have already demonstrated that our gas plasma medical device, the Adtec SteriPlas, has proven antibacterial efficacy and accelerated healing in problematic and non-healing wounds with strong evidence collected from our extensive library of clinical trials and publications. This includes diabetic foot ulcers which are often complicated by biofilm. Over the course of its existence it has shown that no side effects have been reported which offers patients a safe and reliable treatment option. It has also shown that a 2-minute treatment time is sufficient to achieve exceptional results and that it is also a broad spectrum antibacterial with the ability to kill a wide range of Gram-negative and Gram-positive bacterial superinfections.
The PlasmaTact utilizes the same gas plasma technology from the Adtec SteriPlas. The main difference between the two devices is that the PlasmaTact offers a smaller handheld style treatment area of 1cm2 (vs 12cm2 with the SteriPlas) and offers users the ability to change the power output settings (vs the fixed settings with the SteriPlas).
Osteomyelitis (OM) is biofilm infection of the bone and is a common and costly complication in diabetic foot ulcer (DFU) patients often resulting in amputations. Long-term antimicrobial therapy is widely used as a primary treatment for OM or as an adjunct to surgical approaches however, there is a failure rate of up to 35% and an associated increasing prevalence of antimicrobial resistance. There is an urgent clinical need to develop alternative non-antimicrobial approaches to treat infections, and currently there is a lack of credible alternatives in the market for the treatment of OM.
Evaluating the efficacy of gas plasma in OM represents unique challenges as both the biofilm growth and physical characteristics of OM bone will affect the delivery and activity of the plasma. In vitro biofilm model systems offer a means by which rapid, costs effective and standardised evaluation of anti-biofilm treatments can be undertaken.
The PATROL project is a new and exciting collaborative project between Adtec Healthcare and Dr Angela Oates of the University of Hull Wound Healing Group which is supported by NBIC PoC Award. The overall aim of this project is to develop an osteomyelitis biofilm infection model to support the optimisation and evaluation of a cold plasma technology for the management and prevention of OM.
This collaborative project represents the first phase of the novel utilisation of Adtec SteriPlas to treat OM or as an adjunct current therapy. Successful translation of this technology to treat OM will reduce antimicrobial usage and associated OM amputations, reducing NHS costs and ultimately improving patient outcomes.
#osteomyelitis #biofilm #boneinfection #infection #antimicrobial #antimicrobialresistance #amputation #plasma #gasplasma #coldplasma #kaltesplasma #NBIC #universityofhull #podiatry #diabeticfootulcer #diabeticfoot #diabetes #hullyorkmedicalschool
Adtec SteriPlas featured in conference presentations for 2019
Adtec Healthcare is excited to attend and support the clinicians presenting at the following conferences for 2019:
The European Conference on Controversies in Diabetic Foot Management conference in Vienna, 2nd – 3rd May 2019 (https://www.diabeticfoot-europe.com/).
Mr Keith Cutting will be conducting an oral presentation on Friday 3rd May at 14:00. His presentation is titled, “Interim Results from Currently Running Study on the Treatment of Biofilm Infection in Diabetic Foot Ulcers Using Gas Plasma”.
The ISDF 2019 conference in The Netherlands, 22nd – 25th May 2019 (https://diabeticfoot.nl/).
Dr Aye Aye Thant from Kettering General Hospital NHS Foundation Trust will be conducting a poster presentation on “Adtec Cold Plasma Treatment to Assist in Treating Diabetic Foot with Multi Resistant Infection”. This will be presented on Wednesday 22nd May from 12:10.
The European Wound Management Association (EWMA) conference in Gothenburg, Sweden, 5th – 7th June 2019 (https://ewma.org/ewma-conference/2019/). Presenting clinical evidence at this conference will be:
Maurice Moelleken from the Universitätsklinikum Essen, Germany. Maurice’s oral presentation on “Prospective RCT to validate the interval of cold atmospheric plasma treatment for reduction of bacterial load, wound area and pain in patients with chronic wounds” will be presented on 6th June at 08:50am.
Dr Michael Pierides from Kettering General Hospital NHS Foundation Trust will have an e-poster at the EWMA conference. His poster, “The Gas Plasma Medical Device: A Novel Therapy in Treating Non-Resolving Infected Diabetic Foot and Leg Ulcers” can be viewed throughout the conference.
Dr Heinrich Rotering from the Universitätsklinikum Münster, Germany will be conducting a poster presentation, “Cold Plasma and Advanced Negative Pressure Wound Treatment – Long Term Follow Up of Treated Infected Implants in Cardiac Surgery”, on 6th June between 09:42 – 09:45.
The Surgical Infection Society Europe conference in Dublin, Ireland, 26th – 28th June (http://sis-e.org/2019/).
Dr Heinrich Rotering will have a poster at this conference. His poster, “Infection of Cardiovascular Implantable Electronic Devices (CIED) – New Approach with Cold Atmospheric Plasma (CAP)” can be viewed throughout the conference.
Adtec Healthcare staff will be present at these conferences to support the presenting speakers and welcome any meetings. Please get in contact with us at info@adtec.eu.com to secure your meeting in advance.
Gas plasma shows promising results in the treatment of non-healing wounds
Renowned for its ability to successfully treat non-healing wounds, the Adtec SteriPlas is a must have for any dermatology and wound care departments.
This 61-year-old patient with a long-term venous ulcer was stalled from healing and present with Klebsiella oxytoca and Enterobacter cloacae. The patient went through a short treatment programme with our gas plasma medical device to achieve exceptional results. Figures (a) - (b) shows the visual changes of the ulcer throughout the short course of treatment with the Adtec SteriPlas.
At the end of the treatment programme, swabs which would normally have shown signs of bacteria were now sterile, allowing the patient to further progress into full healing.
Interested to hear more? Reach out to us at info@adtec.eu.com
Surgical site infections treated with the Adtec SteriPlas
Surgical site infections (SSIs) are still a severe complication after cardiac surgery with a mortality estimated range of up to 40% of cases. These post-operative wounds are generally associated with longer hospital stay and the delayed or inadequate therapeutic measures can lead to avoidable hospital costs for the healthcare system. The significant cost burden on the hospital for a single SSI case is €36,000. 1
It has already been shown that the Adtec SteriPlas is effective due to its increased penetration depth in SSIs to defeat bacteria even under a layer of biofilm independently to their resistance profile. This includes multi-resistant bacteria that have shown little or no response to antibiotics previously. In combination with advanced negative pressure wound treatment (aNPWT), the Adtec SteriPlas has been praised as a “tissue saving approach” offering patients a favourable treatment method for these complicated and chronic wounds compared to conventional treatment therapies. 2
Studies conducted using the Adtec SteriPlas have shown a significant decrease in the mortality rate coupled with accelerated healing. Patients with infected drivelines such as those with left ventricular assist devices have healed in as quick as 1 week, and patients with sternal SSIs have healed in as quick as 6 days. 2,3
Both patients and doctors have praised the Adtec SteriPlas for its exceptional ability at delivering promising results leading to healing.
Be sure to contact us for more information and to see how our medical device may benefit your patients.
- H. Rotering, Cold atmospheric plasma – New options for infection control in wound management, EWMA 2016.
- H. Rotering, Cold atmospheric plasma and advanced Negative Pressure Wound Treatment – First results of a tissue saving approach for deep surgical site infections, EACTS 2018.
- H. Rotering, Das infizierte Implantat, Komplexe Wundbehandlung – Kaltes atmospherisches Plasma und advanced NPWT in der Herzchirurgie, Chirurgie 2019.